(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Base Information

Chemical Name:(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide
CAS No.:405506-12-9
Molecular Formula:C₃₄H₄₇NO₃Si
Molecular Weight:545.838
Hs Code.:

Synonyms:(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Suppliers and Price of (2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

There total 4 articles about (2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 72297-78-0
(2S)-(tert-butyl)(3-iodo-2-methylpropoxy)diphenylsilane

: 234446-84-5
(1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylbutyramide

: 405506-12-9
(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: (1R,2R)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylbutyramide; With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -73 - 23 ℃;

(2S)-3-tret-butyldiphenylsilyloxy-2-methylpropyl iodide; In tetrahydrofuran; hexane; at 20 ℃; for 24h; Further stages.;
DOI:10.1021/ol016943y

Reference yield:

: 95514-04-8
(R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol

: 405506-12-9
(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 96 percent / PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

2.1: diisopropylamine; LiCl; n-butyllithium / tetrahydrofuran; hexane / -73 - 23 °C

2.2: 97 percent / tetrahydrofuran; hexane / 24 h / 20 °C

With 1H-imidazole; n-butyllithium; iodine; diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol016943y

Reference yield:

: 95514-03-7
(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester

: 405506-12-9
(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 97 percent / DIBAL / toluene; tetrahydrofuran / 2 h / -60 - 0 °C

2.1: 96 percent / PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

3.1: diisopropylamine; LiCl; n-butyllithium / tetrahydrofuran; hexane / -73 - 23 °C

3.2: 97 percent / tetrahydrofuran; hexane / 24 h / 20 °C

With 1H-imidazole; n-butyllithium; iodine; diisobutylaluminium hydride; diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ol016943y