(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol

Base Information

Chemical Name:(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol
CAS No.:405506-13-0
Molecular Formula:C₂₄H₃₆O₂Si
Molecular Weight:384.634
Hs Code.:

Synonyms:(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol

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Technology Process of (2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol

There total 5 articles about (2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 405506-12-9
(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentanoic acid ((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-amide

: 405506-13-0
(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol

Guidance literature:: With n-butyllithium; borane-ammonia complex; diisopropylamine; In tetrahydrofuran; hexane; at -78 - 23 ℃; for 8h;
DOI:10.1021/ol016943y

Reference yield:

: 95514-04-8
(R)-3-(tert-butyldiphenylsilyloxy)-2-methylpropan-1-ol

: 405506-13-0
(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 96 percent / PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

2.1: diisopropylamine; LiCl; n-butyllithium / tetrahydrofuran; hexane / -73 - 23 °C

2.2: 97 percent / tetrahydrofuran; hexane / 24 h / 20 °C

3.1: 93 percent / diisopropylamine; n-butyllithium; boraneammonia complex / tetrahydrofuran; hexane / 8 h / -78 - 23 °C

With 1H-imidazole; n-butyllithium; borane-ammonia complex; iodine; diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol016943y

Reference yield:

: 95514-03-7
(S)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propionic acid methyl ester

: 405506-13-0
(2R,4R)-5-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-4-methyl-pentan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / DIBAL / toluene; tetrahydrofuran / 2 h / -60 - 0 °C

2.1: 96 percent / PPh₃; imidazole; I₂ / CH₂Cl₂ / 2 h / 20 °C

3.1: diisopropylamine; LiCl; n-butyllithium / tetrahydrofuran; hexane / -73 - 23 °C

3.2: 97 percent / tetrahydrofuran; hexane / 24 h / 20 °C

4.1: 93 percent / diisopropylamine; n-butyllithium; boraneammonia complex / tetrahydrofuran; hexane / 8 h / -78 - 23 °C

With 1H-imidazole; n-butyllithium; borane-ammonia complex; iodine; diisobutylaluminium hydride; diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1021/ol016943y