(E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol

Base Information

• Chemical Name: (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol
• CAS No.: 1394929-55-5
• Molecular Formula: C₂₄H₂₅NO₂
• Molecular Weight: 359.468
• Mol file: 1394929-55-5.mol

Synonyms:(E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol

Chemical Property of (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol

Chemical Property:

• Melting Point: 204-206°C
• Storage Temp.: Amber Vial, -20?C Freezer, Under Inert Atmosphere
• Solubility.: Methanol (Sparingly, Heated)

Purity/Quality:

(E)-N,N-Didesmethyl-4-hydroxyTamoxifen ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol

There total 8 articles about (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol (1217237-98-3) → (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol (1394929-55-5)

Guidance literature:

In methanol;

DOI:10.1021/jm400364h

Reference yield:

(E)-4-(1-(4-(2-amino-2-oxoethoxy)phenyl)-2-phenylbut-1-enyl)phenyl Pivalate (1440533-06-1) → (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol (1394929-55-5) + (Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol (1308808-22-1)

Guidance literature:

With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h; Overall yield = 70 percent; Overall yield = 100 mg; Inert atmosphere;

DOI:10.1039/c9cc09754f

Reference yield:

1-phenyl-propan-1-one (93-55-0) → (E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol (1394929-55-5) + (Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol (1308808-22-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: zinc; titanium tetrachloride / tetrahydrofuran / 2.5 h / 0 °C / Inert atmosphere; Reflux; Darkness

2.1: potassium carbonate / acetone / 0.17 h / Reflux

2.2: 3 h

3.1: aluminum (III) chloride; lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; lithium aluminium tetrahydride; titanium tetrachloride; potassium carbonate; zinc; In tetrahydrofuran; acetone;

DOI:10.1039/c9cc09754f

upstream raw materials:

4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-en-1-yl)phenol

1-phenyl-propan-1-one

[4-(4-hydroxybenzoyl)phenyl]-2,2-dimethyl propanoate

(E)-1-(4-hydroxyphenyl)-1-[4-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene

Refernces

• 1、 Lv, Wei,Liu, Jinzhong,Lu, Deshun,Flockhart, David A.,Cushman, Mark. "Synthesis of mixed (E, Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities". . p. 4611 - 4618. Retrieved 2013/07/19.