(E)-1-(4-HYDROXYPHENYL)-1-[4-(TRIMETHYLACETOXY)PHENYL]-2-PHENYLBUT-1-ENE

Base Information

• Chemical Name: (E)-1-(4-HYDROXYPHENYL)-1-[4-(TRIMETHYLACETOXY)PHENYL]-2-PHENYLBUT-1-ENE
• CAS No.: 177748-17-3
• Molecular Formula: C27H28O3
• Molecular Weight: 400.51
• Mol file: 177748-17-3.mol

Synonyms:(E)-1-(4-HYDROXYPHENYL)-1-[4-(TRIMETHYLACETOXY)PHENYL]-2-PHENYLBUT-1-ENE;(E)-2,2-DiMethyl-propanoic Acid 4-[1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl Ester

Chemical Property of (E)-1-(4-HYDROXYPHENYL)-1-[4-(TRIMETHYLACETOXY)PHENYL]-2-PHENYLBUT-1-ENE

Chemical Property:

• Melting Point: 171-173°C
• Boiling Point: 509.3±40.0 °C(Predicted)
• PKA: 10.25±0.15(Predicted)
• Density: 1.109±0.06 g/cm3(Predicted)
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

99% ^*data from raw suppliers

(E)-1-(4-Hydroxyphenyl)-1-[4-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: A analogue of tamoxifen with anti-estrogenic properties A analogue of tamoxifen with anti-estrogenic properties.

Technology Process of (E)-1-(4-HYDROXYPHENYL)-1-[4-(TRIMETHYLACETOXY)PHENYL]-2-PHENYLBUT-1-ENE

There total 17 articles about (E)-1-(4-HYDROXYPHENYL)-1-[4-(TRIMETHYLACETOXY)PHENYL]-2-PHENYLBUT-1-ENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-phenyl-propan-1-one (93-55-0) + [4-(4-hydroxybenzoyl)phenyl]-2,2-dimethyl propanoate (114031-67-3) → 2,2-Dimethyl-propionic acid 4-[(Z)-1-(4-hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenyl ester (177748-17-3) + (E)-1-(4-hydroxyphenyl)-1-[4-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene (177748-17-3)

Guidance literature:

With titanium tetrachloride; zinc; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jo952279l

Reference yield: 82.0%

1-phenyl-propan-1-one (93-55-0) + [4-(4-hydroxybenzoyl)phenyl]-2,2-dimethyl propanoate (114031-67-3) → 2,2-Dimethyl-propionic acid 4-[(Z)-1-(4-hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenyl ester (177748-17-3) + (E)-1-(4-hydroxyphenyl)-1-[4-(trimethylacetoxy)phenyl]-2-phenylbut-1-ene (177748-17-3)

Guidance literature:

With titanium tetrachloride; zinc; In tetrahydrofuran; for 5h; Heating;

DOI:10.1021/jo952279l

Reference yield: 69.0%

1-phenyl-propan-1-one (93-55-0) + [4-(4-hydroxybenzoyl)phenyl]-2,2-dimethyl propanoate (114031-67-3) → 1-(4-trimethylacetoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-ene (364635-60-9,177748-17-3)

Guidance literature:

With titanium tetrachloride; zinc; In tetrahydrofuran; Heating;

DOI:10.1016/S0968-0896(01)00038-4

upstream raw materials:

1-phenyl-propan-1-one

[4-(4-hydroxybenzoyl)phenyl]-2,2-dimethyl propanoate

pivaloyl chloride

3,3-dimethylbutanoic acid chloride

Downstream raw materials:

(Z)-4-(1-(4-(2-amino-2-oxoethoxy)phenyl)-2-phenylbut-1-enyl)phenyl Pivalate

(E)-4-(1-(4-(2-amino-2-oxoethoxy)phenyl)-2-phenylbut-1-enyl)phenyl Pivalate

(Z)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol

(E)-4-(1-(4-(2-aminoethoxy)phenyl)-2-phenylbut-1-enyl)phenol