(R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

Base Information

Chemical Name:(R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide
CAS No.:152298-95-8
Molecular Formula:C₃₂H₄₀N₂O₃Si
Molecular Weight:528.767
Hs Code.:

Synonyms:(R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

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Technology Process of (R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

There total 7 articles about (R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 136918-14-4,85-41-6
phthalimide

: 152299-13-3
(2S)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(dibenzylamino)butan-1-ol

: 152299-02-0
(S)-1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

: 152298-95-8
(R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 16h; Ambient temperature;
DOI:10.1021/jo00101a042

Reference yield: 19.0%

: 1074-82-4
potassium phtalimide

: 152298-92-5
(R)-N,N-dibenzyl-4-<(tert-butyldimethylsilyl)oxy>-2-chloro-1-butylamine

: 152299-02-0
(S)-1-<2-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

: 152298-95-8
(R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃; for 42h;
DOI:10.1016/S0040-4039(00)79340-3

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 152298-95-8
(R)-2-<1-(N,N-dibenzylamino)-4-<(tert-butyldimethylsilyl)oxy>butyl>-N-phthalimide

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / imidazole / dimethylformamide / 2 h / 0 °C

2: 94 percent / MesCl, Et₃N / CH₂Cl₂ / 1.) 0 deg C, 5 min, 2.) 1 h

3: 19 percent / tetrahydrofuran / 48 h / 50 °C

With 1H-imidazole; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00101a042