4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester

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Chemical Name:4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester
CAS No.:123847-39-2
Molecular Formula:C₂₅H₄₀N₆O₄
Molecular Weight:488.63
Hs Code.:

Synonyms:4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester

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Chemical Property of 4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester

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Technology Process of 4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester

There total 7 articles about 4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.4%

: 140135-32-6
C₃₃H₄₅N₇O₈

: 123847-39-2
4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester

Guidance literature:: With hydrogen; Pd catalyst; In water; acetic acid;
DOI:10.1248/cpb.39.2930

Reference yield:

: 27687-13-4
trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carbonyl chloride

: 123847-39-2
4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50.2 percent / Et₃N / CHCl₃; dimethylformamide / Ambient temperature

2: 89.4 percent / hydrogen / Pd catalyst / acetic acid; H₂O

With hydrogen; triethylamine; Pd catalyst; In chloroform; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2930

Reference yield:

: 2304-98-5
N₅-[imino(nitroamino)methyl]-N₂-[(phenylmethoxy)carbonyl]-L-ornithine

: 123847-39-2
4-{(S)-2-[(4-Aminomethyl-cyclohexanecarbonyl)-amino]-5-guanidino-pentanoylamino}-benzoic acid isobutyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) PCl₃, pyridine / 1.) ice-salt cooling, 15 min, then r.t., 30 min, 2.) r.t., overnight

2: 25 percent HBr-AcOH

3: 50.2 percent / Et₃N / CHCl₃; dimethylformamide / Ambient temperature

4: 89.4 percent / hydrogen / Pd catalyst / acetic acid; H₂O

With pyridine; hydrogen bromide; hydrogen; acetic acid; triethylamine; phosphorus trichloride; Pd catalyst; In chloroform; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2930