ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

Base Information

Chemical Name:ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate
CAS No.:1148040-85-0
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

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Chemical Property of ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

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Technology Process of ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

There total 1 articles about ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 65038-91-7
ethyl 3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

: 100-44-7
benzyl chloride

: 1148040-85-0
ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

Guidance literature:: ethyl 3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

benzyl chloride; In N,N-dimethyl-formamide; for 5h; Reflux;
DOI:10.1016/j.bmcl.2009.01.096

Reference yield: 80.0%

: 1148040-85-0
ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

: 109-94-4
formic acid ethyl ester

: ethyl 2-benzyl-5-(hydroxymethylidene)-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate

Guidance literature:: ethyl 2-benzyl-3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylate; With potassium tert-butylate; In toluene; at 0 - 20 ℃; for 3h; Inert atmosphere;

formic acid ethyl ester; In toluene; at 0 - 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.tet.2013.09.003