8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine

Base Information

Chemical Name:8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine
CAS No.:220445-52-3
Molecular Formula:C₂₃H₁₅ClN₄O₂
Molecular Weight:414.851
Hs Code.:

Synonyms:8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine

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Chemical Property of 8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine

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Technology Process of 8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine

There total 7 articles about 8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 304647-12-9
8-chloro-1-(4-nitrophenyl)-3-phenacyl-3,5-dihydro-4H-2,3-benzodiazepin-4-one

: 220445-52-3
8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine

Guidance literature:: With ammonium acetate; In acetic acid; at 140 ℃; for 3h;
DOI:10.1016/S0968-0896(00)00133-4

Reference yield:

: 57962-58-0
rac-2,2-dimethoxy-1-phenylethanamine

: 220444-98-4
8-chloro-1-(4-nitrophenyl)-3,5-dihydro-4H-2,3-benzodiazepin-4-thione

: 220445-52-3
8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine

Guidance literature:: With methanesulfonic acid; In methanol; chloroform;

Reference yield:

: 1875-88-3
2-(4-Chlorophenyl)ethanol

: 220445-52-3
8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 56 percent / ZnCl₂; HCl / benzene

2.1: 78 percent / CrO₃; H₂SO₄ / acetone / 16 h

3.1: NH₂NH₂*H₂O / propan-2-ol / 4 h / Heating

3.2: 88 percent / 1N HCl / 20 °C

4.1: 83 percent / K₂CO₃ / dimethylformamide / 2 h / 80 °C

5.1: 82 percent / NH₄OAc / acetic acid / 3 h / 140 °C

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; ammonium acetate; potassium carbonate; hydrazine hydrate; zinc(II) chloride; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol; acetone; benzene; 1.1: Condensation / 2.1: Oxidation / 3.1: Condensation / 3.2: Cyclization / 4.1: Alkylation / 5.1: Cyclization;
DOI:10.1016/S0968-0896(00)00133-4