57962-58-0

Upstream product

• 1402067-59-7 N,N-dibenzyl-2,2-dimethoxy-1-phenylethanamine 
• 1402067-68-8 N-allyl-N-(2,2-dimethoxy-1-phenylethyl)prop-2-en-1-amine 
• 100-46-9 benzylamine 
• 101582-03-0 benzylamino-phenyl-acetaldehyde dimethylacetal 

Downstream Products

• 220445-52-3 8-chloro-6-(4-nitrophenyl)-2-phenyl-11H-imidazolo[1,2-c][2,3]benzodiazepine 
• 1130734-85-8 (R)-2,2-dimethoxy-1-phenylethanamine 
• 1184944-98-6 (S)-1-phenyl-2,2-dimethoxyethylamine 
• 204461-11-0 C₁₆H₁₅NO₃ 
• 67553-20-2 (+/-)-benzyl 2-hydroxy-1-phenylethylcarbamate 

Relevant academic research and scientific papers

α-amination of aldehydes catalyzed by in situ generated hypoiodite

The metal-free amination of different aldehydes is catalyzed by hypoiodite, which is generated by employing commercially available sodium percarbonate as the co-oxidant. This approach has several advantages: it is a metal-free oxidation that works under m

Resolution and absolute configuration of some a-aminoacetals: En route to enantiopure N-protected a-aminoaldehydes

The first successful resolution of rac-a-aminoacetals via diastereoisomeric salt formation with optically pure N-protected aminoacids is reported. The absolute configuration assignment of a-aminoacetal enantiomers is performed by an entirely non-racemizing chemical correlation method involving N-protection and a new efficient hydrolysis step followed by a reduction of the resulting N-protected a-aminoaldehyde intermediates. A racemization method of optically enriched a-aminoacetals is exemplified to allow valorisation of both enantiomers. Springer-Verlag 2011.

PROCESS FOR PREPARING ALPHA AMINOACETALS IN RECEMIC FORM

The invention relates to a process for preparing an α-aminoacetal, or addition salts thereof, of formula (I) in recemic form comprising the steps consisting in: reacting a glyoxal monoacetal of formula (II) with an arylalkylamine of formula (III) in such a way as to obtain an imine of formula (IV); adding a Grignard reagent of formula R3-Mg-HaI to said imine of formula (IV) so as to obtain an amine of formula (V), and - deprotecting the amine of formula (V) in such a way as to obtain the compound of formula (I) in racemic form, and, where appropriate, adding an inorganic or organic acid in order to obtain an addition salt of the α-aminoacetal of formula (I).

PROCESS FOR THE PREPARATION OF PRIMARY AMINES

Process for the preparation of primary amines of formula (I): on enclosed where R3 represents an alkyl, cycloalkyl or aralkyl group, by reaction of a triazolium salt of formula (II): (formula see on enclosed paper version) where R1 and R2 represent hydrogen or an alkyl, aralkyl or aryl group, R4 represents an alkyl or aralkyl group or a residue of an organic polymer functionalized by an alkylating group, and A- represents a halogen, alkylsulphonate, arylsulphonate, alkyl sulphate, hydrogensulphate, hemisulphate, perchlorate or hydroxide, with a hydride, in order to obtain an amine of formula (I), which is isolated, if desired, and intermediates.