4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester

Base Information

• Chemical Name: 4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester
• CAS No.: 886528-42-3
• Molecular Formula: C₁₄H₁₈BF₃O₃
• Molecular Weight: 302.101
• Mol file: 886528-42-3.mol

Synonyms:4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane

Chemical Property of 4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4,4,5,5-Tetramethyl-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane 95+% ^*data from reagent suppliers

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Technology Process of 4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester

There total 6 articles about 4-(2,2,2-Trifluoroethoxy)phenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-bromo-4-(2,2,2-trifluoro-ethoxy)benzene (106854-77-7) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane (886528-42-3)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield: 42.0%

→ 4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane (886528-42-3)

Guidance literature:

Reference yield: 32.0%

4-bromo-phenol (106-41-2) + 1,1,1-trifluoro-2-(4-methylbenzenesulfonyl)ethane (284031-83-0) + bis(pinacol)diborane (73183-34-3) → 4,4,5,5-tetramethyl-2-(4-(2,2,2-trifluoroethoxy)phenyl)-1,3,2-dioxaborolane (886528-42-3)

Guidance literature:

4-bromo-phenol; 1,1,1-trifluoro-2-(4-methylbenzenesulfonyl)ethane; With potassium carbonate; In N,N-dimethyl-formamide; at 115 - 120 ℃; Inert atmosphere;

bis(pinacol)diborane; With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; In 1,4-dioxane; toluene; at 70 - 75 ℃; Inert atmosphere;

upstream raw materials:

4-bromo-phenol

2,2,2-Trifluoroethyl p-toluenesulfonate

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

1-bromo-4-(2,2,2-trifluoro-ethoxy)benzene

Downstream raw materials:

(2R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-1,2,3,4-tetrazol-1-yl)-1-{5-[4-(2,2,2-trifluoroethoxy)phenyl]pyridin-2-yl}propan-2-ol

C₂₃H₁₅F₇O₂

C₂₂H₁₄F₇NO₂

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