(2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Base Information

Chemical Name:(2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate
CAS No.:114978-18-6
Molecular Formula:C₂₇H₂₆F₃NO₅
Molecular Weight:501.502
Hs Code.:

Synonyms:(2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

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Chemical Property of (2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

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Technology Process of (2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

There total 5 articles about (2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 114957-76-5
diethyl 2-acetyl-4-(5-phenyl-3-isoxazolyl)-3-<2-(trifluoromethyl)phenyl>pentanedioate

: 114978-18-6
(2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: With molybdenum hexacarbonyl; In water; acetonitrile; for 23h; Heating;
DOI:10.1021/jm00403a030

Reference yield: 8.0%

: 447-61-0
2-Trifluoromethylbenzaldehyde

: 86969-12-2
α-benzoylacetoacetic acid ethyl ester

: 41867-20-3
ethyl (E)-3-aminobut-2-enoate

: 114978-18-6
(2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: In ethanol; for 18h; Heating;
DOI:10.1021/jm00403a030

Reference yield:

: 3590-37-2
ethyl 3-nitropropanoate

: 114978-18-6
(2Z,3α,4β)-(+/-)-diethyl 1,2,3,4-tetrahydro-6-methyl-2-(2-oxo-2-phenylethylidene)-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 5.1 percent / triethylamine, phosphorous oxychloride / CHCl₃ / Heating

2: 61 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C

3: 88 percent / molybdenum hexacarbonyl / acetonitrile; H₂O / 23 h / Heating

With molybdenum hexacarbonyl; triethylamine; lithium diisopropyl amide; trichlorophosphate; In tetrahydrofuran; chloroform; water; acetonitrile;
DOI:10.1021/jm00403a030