di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate

Base Information

Chemical Name:di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate
CAS No.:1489126-50-2
Molecular Formula:C₃₄H₄₇NO₆
Molecular Weight:565.75
Hs Code.:

Synonyms:di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate

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Chemical Property of di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate

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Technology Process of di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate

There total 2 articles about di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 540-88-5
acetic acid tert-butyl ester

: 94497-53-7
methyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-carbamoyl]benzoate

: 1489126-48-8
tert-butyl 3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]-3-oxopropionate

: 1489126-50-2
di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate

Guidance literature:: acetic acid tert-butyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

methyl 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-carbamoyl]benzoate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 4h;
DOI:10.1248/cpb.c13-00356

Reference yield:

: 94497-51-5
Am80

: 1489126-50-2
di-tert-butyl 3-hydroxy-3-[4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl]phenyl]glutarate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -20 °C

2.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 4 h / -78 - 20 °C

With n-butyllithium; triethylamine; diisopropylamine; In tetrahydrofuran; hexane;
DOI:10.1248/cpb.c13-00356