methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate

Base Information

Chemical Name:methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate
CAS No.:1049806-16-7
Molecular Formula:C₂₁H₁₉ClF₃NO₄
Molecular Weight:441.834
Hs Code.:

Synonyms:methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate

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Chemical Property of methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate

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Technology Process of methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate

There total 3 articles about methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1049806-15-6
methyl (6-chloro-5-methoxy-2-methyl-1H-indol-3-yl)acetate

: 159689-88-0
3-(trifluoromethoxy)benzyl bromide

: 1049806-16-7
methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate

Guidance literature:: methyl (6-chloro-5-methoxy-2-methyl-1H-indol-3-yl)acetate; With sodium hydride; In N,N-dimethyl-formamide; at 5 ℃; for 0.5h;

3-(trifluoromethoxy)benzyl bromide; In N,N-dimethyl-formamide; at 12 ℃; for 2.5h;

Reference yield:

: 54812-55-4
(3-chloro-4-methoxyphenyl)hydrazine hydrochloride

: 1049806-16-7
methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 2 h / 100 °C

2.1: sulfuric acid / 2 h / 30 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 5 °C

3.2: 2.5 h / 12 °C

With sulfuric acid; sodium hydride; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 926624-33-1
N-ethyl-N-propylammonium methyl (6-chloro-5-methoxy-2-methyl-1H-indol-3-yl)acetate

: 1049806-16-7
methyl (6-chloro-5-methoxy-2-methyl-1-(3-trifluoromethoxybenzyl)-1H-indol-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 2 h / 30 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 5 °C

2.2: 2.5 h / 12 °C

With sulfuric acid; sodium hydride; In N,N-dimethyl-formamide;