N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

Base Information

Chemical Name:N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine
CAS No.:1035216-50-2
Molecular Formula:C₂₄H₂₈ClN₃O₄
Molecular Weight:457.957
Hs Code.:

Synonyms:N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

Suppliers and Price of N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

There total 3 articles about N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.7%

: 1035215-64-5
4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzaldehyde

: 22195-47-7,96894-67-6
4-aminomethyl-2,2-dimethyl[1,3]dioxolane

: 1035216-50-2
N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

Guidance literature:: 4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzaldehyde; 4-aminomethyl-2,2-dimethyl[1,3]dioxolane; With acetic acid; In methanol; at 20 ℃; for 0.166667h;

With sodium cyanoborohydride; In methanol; at 20 ℃;

Reference yield:

: 1035213-80-9
4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzonitrile

: 1035216-50-2
N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

1.2: -40 °C / Inert atmosphere

2.1: acetic acid / methanol / 0.17 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With diisobutylaluminium hydride; acetic acid; In methanol; dichloromethane;

Reference yield:

: 2315-81-3
2-chloro-4-cyanophenol

: 1035216-50-2
N-(4-(3-(3-chloro-4-isopropoxyphenyl)-1,2,4-oxadiazol-5-yl)benzyl)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: hydroxylamine / ethanol; water / 60 °C

3.1: N,N-dimethyl-formamide / 4.33 h / 110 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -40 °C / Inert atmosphere

4.2: -40 °C / Inert atmosphere

5.1: acetic acid / methanol / 0.17 h / 20 °C / Inert atmosphere

5.2: 20 °C / Inert atmosphere

With di-tert-butyl-diazodicarboxylate; hydroxylamine; diisobutylaluminium hydride; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;