N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

Base Information

Chemical Name:N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide
CAS No.:1539317-23-1
Molecular Formula:C₂₄H₂₃FN₆O₂S
Molecular Weight:478.55
Hs Code.:

Synonyms:N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

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Chemical Property of N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

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Technology Process of N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

There total 9 articles about N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1539317-22-0
N-((4aR,7aR)-6-(5-fluoro-4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

: 74-88-4
methyl iodide

: 1539317-23-1
N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1539317-16-2
(3aR,6aR)-tert-butyl 1-((R)-1-phenylethyl)-6a-(pyridin-2-yl)tetrahydro-1H-pyrrolo[3,4-c]isoxazole-5(3H)-carboxylate

: 1539317-23-1
N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: palladium 10% on activated carbon; ammonium formate / methanol; water / 56 h / 65 °C

2: dichloromethane / 1.5 h / -15 °C

3: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 1 h / -40 °C

4: trifluoroacetic acid / dichloromethane / 4 h / 0 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

6: sodium ethanolate / ethanol / 2 h / Reflux

7: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; ammonium formate; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1539317-15-1
tert-butyl N-allyl-N-[2-oxo-2-(2-pyridyl)ethyl]carbamate

: 1539317-23-1
N-((4aR,7aR)-6-(5-fluoro-4-methoxy-6-methylpyrimidin-2-yl)-7a-(pyridin-2-yl)-4,4a.5,6.7.7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: titanium(IV) tetraethanolate / tetrahydrofuran / 97 h / 70 - 80 °C / Sealed tube

2: palladium 10% on activated carbon; ammonium formate / methanol; water / 56 h / 65 °C

3: dichloromethane / 1.5 h / -15 °C

4: trifluoromethylsulfonic anhydride; pyridine / dichloromethane / 1 h / -40 °C

5: trifluoroacetic acid / dichloromethane / 4 h / 0 °C

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 17 h / 20 °C

7: sodium ethanolate / ethanol / 2 h / Reflux

8: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With pyridine; titanium(IV) tetraethanolate; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; ammonium formate; sodium ethanolate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;