Technology Process of (4-Amino-1-benzyl-6,7-dimethoxy-1H-indol-3-yl)-acetic acid ethyl ester
There total 9 articles about (4-Amino-1-benzyl-6,7-dimethoxy-1H-indol-3-yl)-acetic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1: iron dust, 12 M HCl / methanol / 10 h / Heating
2: Na2CO3 / diethyl ether; H2O / 1.) 0 deg C, 30 min; 2.) room temp., 2 h
3: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h
4: tetrahydrofuran / 2 h / Ambient temperature
5: 2 M aq. NaN3 / tetrahydrofuran; H2O / 2 h / Ambient temperature
6: toluene / 0.5 h / Heating
7: toluene / 2 h / 60 °C
8: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h
9: acetonitrile / 1 h
10: NaBH3CN / acetonitrile / 12 h / 50 °C
11: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating
12: 75 percent / 1 M nBu4NF / tetrahydrofuran / 5 h / Ambient temperature
With
hydrogenchloride; sodium azide; jones reagent; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; iron; sodium cyanoborohydride; sodium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1
- Guidance literature:
-
Multi-step reaction with 11 steps
1: Na2CO3 / diethyl ether; H2O / 1.) 0 deg C, 30 min; 2.) room temp., 2 h
2: 93 percent / Jones reagent / acetone / 1.) 0 deg C, 30 min; 2.) room temp., 1 h
3: tetrahydrofuran / 2 h / Ambient temperature
4: 2 M aq. NaN3 / tetrahydrofuran; H2O / 2 h / Ambient temperature
5: toluene / 0.5 h / Heating
6: toluene / 2 h / 60 °C
7: 100 percent / hydrogen / 10percent Pd-C / ethanol / 2 h
8: acetonitrile / 1 h
9: NaBH3CN / acetonitrile / 12 h / 50 °C
10: 85 percent / molecular sieves 3 Angstroem / ethanol / 72 h / Heating
11: 75 percent / 1 M nBu4NF / tetrahydrofuran / 5 h / Ambient temperature
With
sodium azide; jones reagent; 3 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; sodium cyanoborohydride; sodium carbonate;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; water; acetone; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)85065-1
