1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

Base Information

Chemical Name:1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine
CAS No.:1202008-39-6
Molecular Formula:C₂₆H₂₉ClN₂O₂
Molecular Weight:436.981
Hs Code.:

Synonyms:1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

Suppliers and Price of 1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

There total 10 articles about 1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202006-81-2
7-chloro-6-fluoro-1-methoxy-isoquinoline

: 1202008-38-5
(1S,4S,5S)-5-(1-amino-propyl)-5-phenyl-bicyclo[2.2.1]heptan-2-ol

: 1202008-39-6
1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

Guidance literature:: With sodium hydride; In ISOPROPYLAMIDE; at 20 ℃; for 20h;

Reference yield:

: 923021-48-1
7-chloro-6-fluoro-isoquinoline 2-oxide

: 1202008-39-6
1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloroformic acid ethyl ester / -10 °C

1.2: 1 h / -20 °C

2.1: sodium hydride / ISOPROPYLAMIDE / 20 h / 20 °C

With sodium hydride; In ISOPROPYLAMIDE; chloroformic acid ethyl ester;

Reference yield:

: 1202008-33-0
(1S,2S,4S)-5-oxo-2-phenyl-bicyclo[2.2.1]heptane-2-carbonitrile ethylene ketal

: 1202008-39-6
1-[(1S,2S,4S)-5-(7-chloro-1-methoxy-isoquinolin-6-yloxy)-2-phenyl-bicyclo[2.2.1]hept-2-yl]-propylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / tetrahydrofuran; water / 30 h / 20 °C

2.1: sodium tetrahydroborate / ethanol / -70 - 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / -10 - 20 °C

4.1: toluene / 12 h / Reflux

5.1: sodium tetrahydroborate / ethanol / 3 h / 20 °C

6.1: hydrogenchloride / water / pH 3

6.2: pH 12

7.1: sodium hydride / ISOPROPYLAMIDE / 20 h / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; sodium tetrahydroborate; sodium hydride; In tetrahydrofuran; ethanol; dichloromethane; ISOPROPYLAMIDE; water; toluene;