2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Chemical Name:2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide
CAS No.:1313267-49-0
Molecular Formula:C₂₆H₂₈F₄N₄O₃
Molecular Weight:520.527
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Chemical Property of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

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Technology Process of 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

There total 9 articles about 2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1067427-53-5
2,2,2-trifluoro-N-(4-fluoro-3-piperidin-4-yl-benzyl)acetamide hydrochloride

: 1313267-47-8
1-(2-methoxy-ethyl)-7-methyl-1-pyrrolo[2,3-c]pyridine-3-carboxylic acid

: 1313267-49-0
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; Reflux;

Reference yield:

: 1692-15-5
4-pyridylboronic acid

: 1313267-49-0
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 10 h / 80 °C / Inert atmosphere

1.2: 5 °C

2.1: hydrogen / platinum on carbon / methanol / 2585.81 - 3102.97 Torr

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Reflux

With hydrogen; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In tetrahydrofuran; methanol; water; isopropyl alcohol;

Reference yield:

: 202865-68-7
3-bromo-4-fluoro-benzylamine hydrochloride

: 1313267-49-0
2,2,2-trifluoro-N-(4-fluoro-3-{1-[1-(2-methoxy-ethyl)-7-methyl-1H-pyrrolo[2,3-c]pyridine-3-carbonyl]-piperidin-4-yl}-benzyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / isopropyl alcohol; water / 10 h / 80 °C / Inert atmosphere

1.2: 5 °C

2.1: hydrogen / platinum on carbon / methanol / 2585.81 - 3102.97 Torr

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C / Reflux

With hydrogen; sodium hydrogencarbonate; 1,1'-carbonyldiimidazole; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; In tetrahydrofuran; methanol; water; isopropyl alcohol;