4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile

Base Information

Chemical Name:4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile
CAS No.:1174495-31-8
Molecular Formula:C₁₈H₂₁N₃OS
Molecular Weight:327.45
Hs Code.:

Synonyms:4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile

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Chemical Property of 4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile

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Technology Process of 4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile

There total 4 articles about 4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)oxy]-2,6-dimethylbenzonitrile

: 2373-51-5
chloro-methylsulfanyl-methane

: 1174495-31-8
4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile

: 1174495-34-1
C₁₈H₂₁N₃OS

Guidance literature:: 4-[(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)oxy]-2,6-dimethylbenzonitrile; With potassium tert-butylate; In 1,2-dimethoxyethane; at 20 - 22 ℃; Large scale reaction;

chloro-methylsulfanyl-methane; In 1,2-dimethoxyethane; at 20 - 30 ℃; for 3.5h; Large scale reaction;
DOI:10.1021/op900110k

Reference yield:

: 1174495-43-2
4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile hydrogen sulfate

: 1174495-31-8
4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile

Guidance literature:: With water; In ethyl acetate;
DOI:10.1021/op900110k

Reference yield:

: 21573-10-4
1-cyclopropyl-butane-1,3-dione

: 1174495-31-8
4-({3-cyclopropyl-5-methyl-1-[(methylsulfanyl)methyl]-1H-pyrazol-4-yl}oxy)-2,6-dimethylbenzonitrile

: 1174495-34-1
C₁₈H₂₁N₃OS

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide; chloro-trimethyl-silane / dichloromethane / 0 - 5 °C / Large scale reaction

1.2: Reflux; Large scale reaction

1.3: 25 °C / Large scale reaction

2.1: potassium tert-butylate / 1,2-dimethoxyethane / 9.75 h / 20 - 30 °C / Large scale reaction

2.2: Large scale reaction

With N-chloro-succinimide; chloro-trimethyl-silane; potassium tert-butylate; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/op200145j