dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate

Base Information

• Chemical Name: dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate
• CAS No.: 1010093-92-1
• Molecular Formula: C₃₀H₃₁IO₁₄
• Molecular Weight: 742.472
• Mol file: 1010093-92-1.mol

Synonyms:dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate

Chemical Property of dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate

There total 4 articles about dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dimethyl 3-hydroxy-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate (1010093-94-3) + 2-iodo-3,4,5-trimethoxybenzoic acid (98799-41-8) → dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate (1010093-92-1)

Guidance literature:

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;

DOI:10.1016/j.tetlet.2007.11.154

Reference yield:

dimethyl 3-benzyloxy-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate (1010093-99-8) → dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate (1010093-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 15 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol;

DOI:10.1016/j.tet.2011.01.004

Reference yield:

5-Benzyloxy-3-hydroxy-4-methoxybenzoesaeuremethylester (135388-93-1) → dimethyl 3-(2-iodo-3,4,5-trimethoxybenzoyloxy)-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate (1010093-92-1)

Guidance literature:

Multi-step reaction with 3 steps

1: copper / 4 h / 200 °C / Inert atmosphere; neat (no solvent)

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 15 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; copper; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; 1: Ullmann condensation;

DOI:10.1016/j.tet.2011.01.004

upstream raw materials:

dimethyl 3-hydroxy-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate

2-iodo-3,4,5-trimethoxybenzoic acid

dimethyl 3-benzyloxy-2,2',3',4'-tetramethoxy-1,1'-diphenylether-5,6'-dicarboxylate

methyl 2-bromo-3,4,5-trimethoxybenzoate