98799-41-8

Upstream product

• 1916-07-0 3,4,5-trimethoxybenzoic acid methyl ester 
• 118-41-2 Eudesmic acid 
• 3840-31-1 (3,4,5-trimethoxyphenyl)methanol 
• 665004-29-5 6,6'-bis(2-iodo-3,4,5-trimethoxybenzyl 1,3-benzodioxole-5-carboxylate) 

Downstream Products

• 98799-68-9 2-(6-Isopropoxy-7-methoxy-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-3,4,5-trimethoxy-benzoic acid 
• 139058-94-9 2-iodo-3,4,5-trimethoxybenzoyl chloride 
• 98799-67-8 3,4,5-Trimethoxy-2-(6-methoxy-1-oxo-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzoic acid 
• 665004-28-4 6-iodo-1,3-benzodioxol-5-ylmethyl 2-iodo-3,4,5-trimethoxybenzoate 
• 669053-61-6 C₄₉H₅₂I₂O₁₄ 
• 52562-43-3 methyl 2,3,4,5-tetrakis(3,4,5-trimethoxybenzoyl)-α-D-glucopyranoside 

Relevant academic research and scientific papers

Synthesis, characterization, and crystal structure of 2-iodo-3,4,5- trimethoxybenzoic acid

This work describes the synthesis of 2-iodo-3,4,5-trimethoxybenzoic acid. The combination of iodine and silver trifluoroacetate (AgTFA) reagents was used successfully for the iodination of 3,4,5-trimetoxybenzoic acid. To improve the efficiency of the synt

Intramolecular biaryl coupling reaction of benzyl benzoate and phenyl benzoate derivatives, and its application to the formal synthesis of (-)-steganone

Construction of the biaryl moiety of stegane and related compounds through an intramolecular biaryl coupling reaction is described. Undesired products were obtained by the intramolecular coupling reaction of benzyl benzoates (8, 13, and 14) because of the

Total Synthesis of (+)-Isoschizandrin Utilizing a Samarium(II) Iodide-Promoted 8-Endo Ketyl-Olefin Cyclization

The 13-step synthesis of (+)-isoschizandrin reported herein features a samarium(II) iodide-promoted 8-endo ketyl-olefin coupling to assemble the eight-membered ring present in the target concomitantly with the required functionality and stereochemistry. In constructing (+)-isoschizandrin as a single atropisomer, the synthesis utilizes a kinetic resolution of a seven-membered lactone using a CBS-oxazaborolidine.

Direct Synthesis of Benzophenanthridines and Benzophenanthridones via SRN1 Reactions

A straightforward and high-yield route to the 11,12-dihydrobenzophenanthridine (3) and 11,12-dihydrobenzophenanthridone (14) ring systems is based upon an SRN1 reaction between 2-halobenzylamines 1 or 2-halobenzoic acids 11 and enolates derived from tetralones 2.The efficient dehydrogenation of 3 or 14 gives the benzophenthridines 4 or benzophenanthridones 15.Use of properly substituted reactants leads to nitidine, avicine, and fagaronine and to analogues of those natural products.

Synthesis of 3,4-O-(3,3',4,4',5,5'-Hexamethoxydiphenoyl)-L-arabinopyranose

3,4-O-(3,3',4,4',5,5'-Hexamethoxydiphenoyl)-L-arabinopyranose (Ib) has been synthesized by condensation of 1-O-(3,4,5-tri-O-methylgalloyl)-L-arabinose (IV) with hexamethoxydiphenoyl chloride (IIIb) in pyridine in the presence of triethylamine and subsequent removal of the protecting galloyl group.The synthetic Ib has been found to be identical (m.m.p., co-TLC, IR) with methyl ether of the natural 3,4-O-(3,3',4,4',5,5'-hexahydroxyphenoyl)-L-arabinopyranose (Ia).