1-BOC-4-ETHOXYCARBONYL PIPERAZINE

Base Information

• Chemical Name: 1-BOC-4-ETHOXYCARBONYL PIPERAZINE
• CAS No.: 219509-82-7
• Molecular Formula: C₁₂H₂₂N₂O₄
• Molecular Weight: 258.318
• Mol file: 219509-82-7.mol

Synonyms:1,4-Piperazinedicarboxylicacid, 1,1-dimethylethyl ethyl ester (9CI)

Chemical Property of 1-BOC-4-ETHOXYCARBONYL PIPERAZINE

Chemical Property:

• PSA: 59.08000
• LogP: 1.57140

Purity/Quality:

97% ^*data from raw suppliers

1-Boc-4-ethoxycarbonyl piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-ETHOXYCARBONYL PIPERAZINE

There total 3 articles about 1-BOC-4-ETHOXYCARBONYL PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate (219509-82-7)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 83.0%

ethanol (64-17-5) + 1,1'-carbonyldiimidazole (530-62-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate (219509-82-7)

Guidance literature:

1,1'-carbonyldiimidazole; 1-t-Butoxycarbonylpiperazine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

ethanol; In N,N-dimethyl-formamide; at 60 ℃; for 1h;

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate (219509-82-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2012.02.081

upstream raw materials:

chloroformic acid ethyl ester

1-t-Butoxycarbonylpiperazine

ethanol

1,1'-carbonyldiimidazole