1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

Base Information

Chemical Name:1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester
CAS No.:147471-16-7
Molecular Formula:C₁₆H₁₇N₃O₄
Molecular Weight:315.329
Hs Code.:

Synonyms:1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

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Chemical Property of 1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

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Technology Process of 1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

There total 4 articles about 1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 147471-15-6
2<1-<4-(1H-imidazol-1-yl)phenyl>-2-nitroethyl>-1,3-propanedioic acid diethyl ester

: 147471-16-7
1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 0.5h; Ambient temperature;
DOI:10.1021/jm00060a012

Reference yield:

: 10040-98-9
1-(4-formylphenyl)-1H-imidazole

: 147471-16-7
1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / piperidine, acetic acid / benzene / 28 h / Heating

2: 98 percent / tetramethylguanidine / 2 h / -20 °C

3: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

With piperidine; 1,1,3,3-tetramethylguanidine; ammonium formate; acetic acid; palladium on activated charcoal; In methanol; benzene;
DOI:10.1021/jm00060a012

Reference yield:

: 147471-14-5
2-<<4-(1H-imidazol-1-yl)phenyl>methylene>-1,3-propanedioic acid diethyl ester

: 147471-16-7
1-hydroxy-4-<4-(1H-imidazol-1-yl)phenyl>-2-oxopyrrolidine-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / tetramethylguanidine / 2 h / -20 °C

2: 64 percent / ammonium formate / 10percent Pd/C / methanol / 0.5 h / Ambient temperature

With 1,1,3,3-tetramethylguanidine; ammonium formate; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00060a012