benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate

Base Information

• Chemical Name: benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate
• CAS No.: 1051863-82-1
• Molecular Formula: C₂₆H₂₇NO₅
• Molecular Weight: 433.504
• Mol file: 1051863-82-1.mol

Synonyms:benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate

Chemical Property of benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate

Chemical Property:

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Technology Process of benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate

There total 1 articles about benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid (184033-42-9) + benzyl bromide (100-39-0) → benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate (1051863-82-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00544

Reference yield: 84.0%

benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate (1051863-82-1) + 1-bromomethyl-4-bromobenzene (589-15-1) → benzyl 2-(benzyloxy)-4-((4-bromobenzyl)(tert-butoxycarbonyl)amino)benzoate

Guidance literature:

benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate; With potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

1-bromomethyl-4-bromobenzene; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00544

Reference yield: 78.0%

benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate (1051863-82-1) + benzyl 4-(4-(bromomethyl)phenyl)piperidine-1-carboxylate → benzyl 4-(4-(((3-(benzyloxy)-4-((benzyloxy)carbonyl)phenyl)(tert-butoxycarbonyl)amino)methyl)-phenyl)piperidine-1-carboxylate

Guidance literature:

benzyl 2-(benzyloxy)-4-((tert-butoxycarbonyl)amino)benzoate; With potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.166667h; Inert atmosphere;

benzyl 4-(4-(bromomethyl)phenyl)piperidine-1-carboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00544

upstream raw materials:

4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid

benzyl bromide

Downstream raw materials:

benzyl 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoate