erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one

Base Information

• Chemical Name: erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one
• CAS No.: 136490-98-7
• Molecular Formula: C₂₃H₂₃NO₃
• Molecular Weight: 361.441
• Mol file: 136490-98-7.mol

Synonyms:erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one

Chemical Property of erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one

There total 4 articles about erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

methanol (67-56-1) + trans-2'-benzylaminochalcone epoxide (136490-93-2) → erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one (136490-98-7)

Guidance literature:

With hydrogenchloride; for 24h; Ambient temperature;

DOI:10.1080/00397919108021059

Reference yield:

1-<2-(Benzylamino)phenyl>ethanon (104014-46-2) → erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one (136490-98-7)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOH / ethanol / 24 h

2: 80 percent / 30percent H₂O₂, 10percent aq. NaOH / methanol / 24 h / Ambient temperature

3: 52 percent / HCl / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; In methanol; ethanol;

DOI:10.1080/00397919108021059

Reference yield:

2'-benzylaminochalcone (131423-40-0) → erythro-2-hydroxy-3-methoxy-1-(2'-benzylaminophenyl)-3-phenylpropan-1-one (136490-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / 30percent H₂O₂, 10percent aq. NaOH / methanol / 24 h / Ambient temperature

2: 52 percent / HCl / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; In methanol;

DOI:10.1080/00397919108021059

upstream raw materials:

methanol

trans-2'-benzylaminochalcone epoxide

1-<2-(Benzylamino)phenyl>ethanon

2'-benzylaminochalcone

Downstream raw materials:

threo-1-(2'-benzylaminobenzoyl)-2-phenylethylene chlorohydrin