(1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

Base Information

Chemical Name:(1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester
CAS No.:1288977-80-9
Molecular Formula:C₁₉H₂₁ClN₂O₆S₂
Molecular Weight:472.971
Hs Code.:

Synonyms:(1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

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Chemical Property of (1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

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Technology Process of (1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

There total 1 articles about (1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 856448-69-6
(1S,2R,3R)-1-amino-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

: 58457-24-2
5-chloro-4-nitro-2-thiophenesulfonyl chloride

: 1288977-80-9
(1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: With pyridine; at 0 - 20 ℃; for 12h;
DOI:10.1021/jm101609j

Reference yield: 50.0%

: 1288977-80-9
(1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

: 198985-47-6
2-(trimethylstannyl)-5-chloropyridine

: 1288977-82-1
(1S,2R,3R)-1-[5-(5-chloropyridin-2-yl)-4-nitrothiophene-2-sulfonylamino]-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

Guidance literature:: With trans benzyl(chloro)bis(triphenylphosphine)palladium(II); In toluene; at 120 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm101609j

Reference yield:

: 1288977-80-9
(1S,2R,3R)-1-(5-chloro-4-nitrothiophene-2-sulfonylamino)-2-methyl-3-phenylcyclopropanecarboxylic acid tert-butyl ester

: 1288978-93-7
C₂₄H₂₄ClN₃O₄S₂

Guidance literature:: Multi-step reaction with 2 steps

1: trans benzyl(chloro)bis(triphenylphosphine)palladium(II) / toluene / 12 h / 120 °C / Inert atmosphere

2: triethyl phosphite / 1,3,5-trimethyl-benzene / 8 h / 150 °C / Inert atmosphere

With trans benzyl(chloro)bis(triphenylphosphine)palladium(II); triethyl phosphite; In toluene; 1,3,5-trimethyl-benzene;
DOI:10.1021/jm101609j