856448-69-6Relevant academic research and scientific papers
Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors
Shiozaki, Makoto,Imai, Hiroto,Maeda, Katsuya,Miura, Tomoya,Yasue, Katsutaka,Suma, Akira,Yokota, Masahiro,Ogoshi, Yosuke,Haas, Julia,Fryer, Andrew M.,Laird, Ellen R.,Littmann, Nicole M.,Andrews, Steven W.,Josey, John A.,Mimura, Takayuki,Shinozaki, Yuichi,Yoshiuchi, Hiromi,Inaba, Takashi
scheme or table, p. 6213 - 6217 (2010/06/19)
A series of 1-sulfonylaminocyclopropanecarboxylates was synthesized as ADAMTS-5 (Aggrecanase-2) inhibitors. After an intensive investigation of the central cyclopropane core including its absolute stereochemistry and substituents, we found compound 22 wit
CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF
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Page/Page column 182-183, (2008/06/13)
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula
