[1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL BENZENECARBOXYLATE

Base Information

• Chemical Name: [1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL BENZENECARBOXYLATE
• CAS No.: 338419-16-2
• Molecular Formula: C₁₆H₁₂ClN₃O₂
• Molecular Weight: 313.743
• Mol file: 338419-16-2.mol

Synonyms:(1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl benzoate

Chemical Property of [1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL BENZENECARBOXYLATE

Chemical Property:

Purity/Quality:

[1-(4-Chlorophenyl)-1H-1,2,3-triazol-4-yl]methyl benzenecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL BENZENECARBOXYLATE

There total 4 articles about [1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]METHYL BENZENECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-azido-4-chlorobenzene (3296-05-7) + propargyl benzoate (6750-04-5) → (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl benzoate (338419-16-2)

Guidance literature:

With copper(II) ions-supported on hyperbranchedpolyethylenimine; In water; at 20 ℃; for 24h; Catalytic behavior; Green chemistry;

DOI:10.1016/j.jorganchem.2019.120881

Reference yield:

1‐(4‐chlorophenyl)‐1H‐1,2,3‐triazole‐4‐yl‐methanol (133902-66-6) + benzoyl chloride (98-88-4) → (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl benzoate (338419-16-2)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1016/j.ejmech.2013.12.039

Reference yield:

4-chloro-aniline (106-47-8) → (1-(4-chlorophenyl)-1H-1,2,3-triazole-4-yl)methyl benzoate (338419-16-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

1.2: 1 h / 0 - 5 °C

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

3.1: dmap; pyridine / dichloromethane / 20 °C

With pyridine; hydrogenchloride; dmap; copper(ll) sulfate pentahydrate; sodium L-ascorbate; sodium nitrite; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1016/j.ejmech.2013.12.039

upstream raw materials:

1‐(4‐chlorophenyl)‐1H‐1,2,3‐triazole‐4‐yl‐methanol

benzoyl chloride

4-chloro-aniline

1-azido-4-chlorobenzene