(1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:(1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide
CAS No.:1369766-54-0
Molecular Formula:C₂₂H₂₀F₂N₄O₃
Molecular Weight:426.423
Hs Code.:

Synonyms:(1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

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Chemical Property of (1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

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Technology Process of (1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

There total 10 articles about (1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369769-18-5
(1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-({[1-(methoxymethyl)-2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl]oxy}methyl)cyclopropanecarboxamide

: 1369766-54-0
(1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: (1R,2S)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)-2-({[1-(methoxymethyl)-2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl]oxy}methyl)cyclopropanecarboxamide; With hydrogenchloride; water; In ethanol; at 90 ℃; for 0.5h;

With sodium hydroxide; In ethanol; water; at 10 - 35 ℃;

Reference yield:

: 6622-92-0
4-hydroxy 2,6-dimethylpyrimidine

: 1369766-54-0
(1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium hydroxide; iodine / water / 2 h / 120 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / -40 - 35 °C

3.1: caesium carbonate / 1,10-Phenanthroline; copper(l) iodide / toluene / 120 h / 110 °C

4.1: hydrogen / palladium on activated charcoal / ethyl acetate / 1 h

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 35 °C / Cooling with ice

6.1: sodium hydroxide; water / ethanol / 0.5 h / 10 - 35 °C

7.1: Dess-Martin periodane / dichloromethane / 1 h / 35 °C / Cooling with ice

8.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 1 h / 10 - 35 °C

9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 10 - 90 °C

10.1: hydrogenchloride; water / ethanol / 0.5 h / 90 °C

10.2: 10 - 35 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; water; hydrogen; iodine; caesium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; copper(l) iodide; 1,10-Phenanthroline; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 5.1: Mitsunobu reaction;

Reference yield:

: 83410-37-1
5-iodo-2,6-dimethyl-pyrimidin-4-ol

: 1369766-54-0
(1R,2S)-2-{[(2,4-dimethyl-6-oxo-1,6-dihydropyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / -40 - 35 °C

2.1: caesium carbonate / 1,10-Phenanthroline; copper(l) iodide / toluene / 120 h / 110 °C

3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 1 h

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 35 °C / Cooling with ice

5.1: sodium hydroxide; water / ethanol / 0.5 h / 10 - 35 °C

6.1: Dess-Martin periodane / dichloromethane / 1 h / 35 °C / Cooling with ice

7.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 1 h / 10 - 35 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 10 - 90 °C

9.1: hydrogenchloride; water / ethanol / 0.5 h / 90 °C

9.2: 10 - 35 °C

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; di-isopropyl azodicarboxylate; water; hydrogen; caesium carbonate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide; copper(l) iodide; 1,10-Phenanthroline; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; 4.1: Mitsunobu reaction;