N-(sec-butyl)-2-chloroacetamide

Base Information

• Chemical Name: N-(sec-butyl)-2-chloroacetamide
• CAS No.: 32322-73-9
• Molecular Formula: C6H12 Cl N O
• Molecular Weight: 149.62
• Hs Code.: 2924199090
• European Community (EC) Number: 808-694-4
• DSSTox Substance ID: DTXSID50389711
• Mol file: 32322-73-9.mol

Synonyms:N-(sec-butyl)-2-chloroacetamide;32322-73-9;N-butan-2-yl-2-chloroacetamide;N-(butan-2-yl)-2-chloroacetamide;N-sec-Butyl-2-chloroacetamide;MFCD00791326;N-sec-butyl-2-chloracetamide;SCHEMBL4821600;DTXSID50389711;NQOKLKIMNNTVAC-UHFFFAOYSA-N;BBL003704;STK501922;AKOS000266057;AKOS016051262;VS-01403;CS-0307562;FT-0679566;EN300-01971;Z56853748

Chemical Property of N-(sec-butyl)-2-chloroacetamide

Chemical Property:

• Melting Point: 45.5°C
• Refractive Index: 1.5618 (estimate)
• PSA: 29.10000
• Density: 1.0823 (rough estimate)
• LogP: 1.53080
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 149.0607417
• Heavy Atom Count: 9
• Complexity: 95.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(sec-Butyl)-2-chloroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(C)NC(=O)CCl

Technology Process of N-(sec-butyl)-2-chloroacetamide

There total 4 articles about N-(sec-butyl)-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

SEC-BUTYLAMINE (33966-50-6) + chloroacetyl chloride (79-04-9) → β-chloro-(N-sec-butyl)glycinamide (32322-73-9)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h;

DOI:10.1139/cjc-2012-0358

Reference yield:

isobutylamine (78-81-9) + chloroacetyl chloride (79-04-9) → β-chloro-(N-sec-butyl)glycinamide (32322-73-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 23 ℃; for 2h;

Reference yield:

SEC-BUTYLAMINE (33966-50-6) + dichloroethyne (7572-29-4) → β-chloro-(N-sec-butyl)glycinamide (32322-73-9) + α-chloro-N,N'-di(sec-butyl)ethylimine + N,N'-Di-sec-butyl-2-sec-butylamino-acetamidine + N-sec-Butyl-2-sec-butylamino-N-(sec-butylcarbamoyl-methyl)-acetamide

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In hexane; water; Further byproducts given; Ambient temperature;

upstream raw materials:

SEC-BUTYLAMINE

chloroacetyl chloride

dichloroethyne

isobutylamine

Refernces

• 1、 -. "TREATMENT OF INFECTIOUS DISEASES WITH GLUCOSE UPTAKE INHIBITORS". Paragraph 0171; 0172. . Retrieved 2017/01/09.
• 2、 Pielichowski, Jan,Czub, Piotr. "REACTIONS OF DICHLOROACETYLENE WITH PRIMARY ALIPHATIC AMINES". . p. 407 - 410. Retrieved 2007/10/02.