ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE
• CAS No.: 327-21-9
• Molecular Formula: C12H10 F3 N O2
• Molecular Weight: 0
• Hs Code.: 2933990090
• Mol file: 327-21-9.mol

Synonyms:Indole-2-carboxylicacid, 6-(trifluoromethyl)-, ethyl ester (6CI,8CI); 6-Trifluoromethyl-1H-indole-2-carboxylicacid ethyl ester

Chemical Property of ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE

Chemical Property:

• PSA: 42.09000
• LogP: 3.36340
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl6-(trifluoromethyl)-1H-indole-2-carboxylate 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE

There total 8 articles about ETHYL 6-(TRIFLUOROMETHYL)-INDOLE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

C12H10F3N3O2 → ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate (327-21-9)

Guidance literature:

In acetonitrile; at 20 - 25 ℃; for 1.5h; Inert atmosphere; Irradiation;

DOI:10.1055/s-0036-1590861

Reference yield: 44.6%

ethyl (Z)-2-acetylamino-3-[4-(trifluoromethyl)phenyl]-2-propenoate (312300-41-7) → ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate (327-21-9)

Guidance literature:

With potassium carbonate; In water; toluene; at 100 ℃; for 16h;

DOI:10.1021/acs.orglett.6b01592

Reference yield: 20.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 3-trifluoromethylaniline (98-16-8) → ethyl 6-(trifluoromethyl)-1H-indole-2-carboxylate (327-21-9)

Guidance literature:

With oxygen; palladium diacetate; acetic acid; In dimethyl sulfoxide; at 80 ℃; for 36h; under 760.051 Torr; regioselective reaction; Schlenk technique; Molecular sieve;

DOI:10.1021/acs.joc.8b02180

upstream raw materials:

(E)-ethyl 2-(2-(3-trifluoromethylphenyl)hydrazin-1-ylidene)propanoate

ethyl (Z)-2-acetylamino-3-[4-(trifluoromethyl)phenyl]-2-propenoate

4-Trifluoromethylbenzaldehyde

(Z)-2-methyl-4-[4-(trifluoromethyl)benzylidene]-5(4H)-oxazolone

Downstream raw materials:

6-(trifluoromethyl)-1H-indole-2-carboxylic acid

diethyl 1H-indole-2,6-dicarboxylate

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