isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate

Base Information

Chemical Name:isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate
CAS No.:1220903-12-7
Molecular Formula:C₃₀H₄₀Cl₂N₂O₅
Molecular Weight:579.564
Hs Code.:

Synonyms:isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate

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Chemical Property of isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate

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Technology Process of isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate

There total 5 articles about isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1336888-76-6
(R)-isopropyl 4-(1-amino-4,4-dimethylpentyl)benzoate hydrochloride

: 369403-30-5
2-((tert-butoxycarbonyl)amino)-2-(3,5-dichlorophenyl)acetic acid

: 1220903-12-7
isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm401858f

Reference yield:

: 619-66-9
4-Carboxybenzaldehyde

: 1220903-12-7
isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 64 h / 70 °C

2.1: caesium carbonate / dichloromethane / 30 h / 42 °C

3.1: iodine; magnesium / diethyl ether / 2.75 h / Reflux; Inert atmosphere

3.2: 2 h / -78 - 20 °C

3.3: 0 °C

4.1: hydrogenchloride; methanol / 1,4-dioxane / 1.5 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / acetonitrile / 18 h / 25 °C

With hydrogenchloride; methanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; potassium carbonate; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1220904-43-7
(S)-isopropyl 4-((tert-butylsulfinylimino)methyl)benzoate

: 1220903-12-7
isopropyl 4-((1R)-1-(2-(tert-butoxycarbonylamino)-2-(3,5-dichlorophenyl)acetamido)-3,3-dimethylbutyl)-benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / diethyl ether / 2.75 h / Reflux; Inert atmosphere

1.2: 2 h / -78 - 20 °C

1.3: 0 °C

2.1: hydrogenchloride; methanol / 1,4-dioxane / 1.5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / acetonitrile / 18 h / 25 °C

With hydrogenchloride; methanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; magnesium; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; diethyl ether; acetonitrile;