1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

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Chemical Name:1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one
CAS No.:1616373-10-4
Molecular Formula:C₂₃H₂₉ClN₄O
Molecular Weight:412.962
Hs Code.:

Synonyms:1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

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Chemical Property of 1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

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Technology Process of 1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

There total 6 articles about 1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454928-30-3
1-(4-(tert-butyl)benzyl)-N-ethylhydrazinecarboxamide monomethanesulfonate

: 1211579-64-4
4-(6-chloropyridin-2-yl)butanoic acid

: 1616373-10-4
1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: 4-(6-chloropyridin-2-yl)butanoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-(4-(tert-butyl)benzyl)-N-ethylhydrazinecarboxamide monomethanesulfonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 5140-72-7
2-bromo-6-chloro-pyridine

: 1616373-10-4
1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 2 h / 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 24 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1268520-42-8
ethyl 4-(6-chloropyridin-2-yl)butanoate

: 1616373-10-4
1-(4-(tert-butyl)benzyl)-3-(3-(6-chloropyridin-2-yl)propyl)-4-ethyl-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; methanol; water / 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 24 h / 20 °C

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;