2(3H)-Benzothiazolone,7-chloro-6-fluoro-,hydrazone(9CI)

Base Information

• Chemical Name: 2(3H)-Benzothiazolone,7-chloro-6-fluoro-,hydrazone(9CI)
• CAS No.: 218155-19-2
• Molecular Formula: C₇H₅ClFN₃S
• Molecular Weight: 217.654
• Mol file: 218155-19-2.mol

Synonyms:2(3H)-Benzothiazolone,7-chloro-6-fluoro-, hydrazone (9CI); 7-Chloro-6-fluoro-2-hydrazinobenzothiazole

Chemical Property of 2(3H)-Benzothiazolone,7-chloro-6-fluoro-,hydrazone(9CI)

Chemical Property:

• PSA: 79.18000
• LogP: 3.14770

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(3H)-Benzothiazolone,7-chloro-6-fluoro-,hydrazone(9CI)

There total 2 articles about 2(3H)-Benzothiazolone,7-chloro-6-fluoro-,hydrazone(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-amino-6-fluoro-7-chloro-1,3-benzothiazole (101337-93-3) → 7-chloro-6-fluoro-2-hydrazinylbenzo[d]thiazole (218155-19-2)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In water; ethylene glycol; at 5 - 10 ℃; for 2h; Reflux;

DOI:10.1002/ardp.201100072

Reference yield:

3-chloro-4-fluorophenylamine (367-21-5) → 7-chloro-6-fluoro-2-hydrazinylbenzo[d]thiazole (218155-19-2)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine; acetic acid / 14 h / 5 - 20 °C

2: hydrogenchloride; hydrazine hydrate / water; ethylene glycol / 2 h / 5 - 10 °C / Reflux

With hydrogenchloride; bromine; hydrazine hydrate; acetic acid; In water; ethylene glycol;

DOI:10.1002/ardp.201100072

Reference yield: 82.0%

7-chloro-6-fluoro-2-hydrazinylbenzo[d]thiazole (218155-19-2) + N-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(4-dimethylamino)phenylacrylamide (1311166-13-8) → 7-chloro-N-(1-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-5-(4-(dimethylamino)phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-6-fluorobenzo[d]thiazol-2-amine (1311166-19-4)

Guidance literature:

With acetic acid; In ethanol; for 8h; Reflux;

DOI:10.1002/ardp.201100072

upstream raw materials:

3-chloro-4-fluorophenylamine

2-amino-6-fluoro-7-chloro-1,3-benzothiazole

Downstream raw materials:

7-chloro-N-(1-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-5-(4-(dimethylamino)phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-6-fluorobenzo[d]thiazol-2-amine

4-(1-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(7-chloro-6-fluorobenzo[d]thiazol-2-yl-amino)-4,5-dihydro-1H-pyrazol-5-yl)phenol

4-(1-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-3-(7-chloro-6-fluorobenzo[d]thiazol-2-ylamino)-4,5-dihydro-1H-pyrazol-5-yl)-2-methoxyphenol

7-chloro-N-(1-(7-chloro-6-fluorobenzo[d]thiazol-2-yl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-6-fluorobenzo[d]thiazol-2-amine

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