(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide
CAS No.:1453070-26-2
Molecular Formula:C₁₄H₁₈F₅NOS
Molecular Weight:343.361
Hs Code.:

Synonyms:(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Chemical Property:

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Technology Process of (S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

There total 8 articles about (S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1453070-25-1
C₁₃H₁₄F₅NOS

: 75-16-1
methylmagnesium bromide

: 1453070-26-2
(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: In tetrahydrofuran; dichloromethane; at -60 - 20 ℃; for 5h;

Reference yield:

: 328-67-6
3-bromo-5-(trifluoromethyl)benzoic acid

: 1453070-26-2
(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 0 °C

2.1: triethylamine / dichloromethane / 1 h / 0 °C

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 1.5 h / 0 °C

5.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere

6.1: ozone; oxygen / dichloromethane / -78 °C

6.2: 20 h / 20 °C / Inert atmosphere

7.1: titanium(IV) isopropylate / tetrahydrofuran / 20 h / 0 - 20 °C

8.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C

With titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; oxalyl dichloride; diethylamino-sulfur trifluoride; oxygen; diisobutylaluminium hydride; ozone; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 880652-44-8
3-bromo-N-methoxy-N-methyl-5-(trifluoromethyl)benzamide

: 1453070-26-2
(S)-N-((R)-1-(3-(difluoromethyl)-5-(trifluoromethyl)phenyl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.33 h / -40 - 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 1.5 h / 0 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere

4.1: ozone; oxygen / dichloromethane / -78 °C

4.2: 20 h / 20 °C / Inert atmosphere

5.1: titanium(IV) isopropylate / tetrahydrofuran / 20 h / 0 - 20 °C

6.1: dichloromethane; tetrahydrofuran / 5 h / -60 - 20 °C

With titanium(IV) isopropylate; bis-triphenylphosphine-palladium(II) chloride; diethylamino-sulfur trifluoride; oxygen; diisobutylaluminium hydride; ozone; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;