pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate

Base Information

Chemical Name:pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate
CAS No.:900811-42-9
Molecular Formula:C₃₂H₄₀N₂O₆S
Molecular Weight:580.745
Hs Code.:

Synonyms:pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate

There total 5 articles about pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 900811-41-8
(2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanoic acid

: 4556-23-4
pyridine-4-thiol

: 900811-42-9
pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 3.5h;
DOI:10.1021/jo060296c

Reference yield:

: 900811-40-7
methyl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanoate

: 900811-42-9
pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / tetrahydrofuran; methanol / 3.5 h / 20 °C

2: 94 percent / EDCI / CH₂Cl₂ / 3.5 h / 0 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo060296c

Reference yield:

: 172900-69-5
(R)-4-(2-(bromomethyl)-3-methylbutyl)-1-methoxy-2-(3-methoxypropoxy)benzene

: 900811-42-9
pyridin-4-yl (2S,4S)-2-[[(phenylmethoxy)carbonyl]amino]-4-methoxy-3-(3-methoxypropoxy)-γ-(1-methylethyl)benzenepentanethioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran / -75 °C

1.2: 90 percent / tetrahydrofuran / -75 - -18 °C

2.1: 99 percent / HCl / H₂O; acetonitrile

3.1: 89 percent / pyridine / CH₂Cl₂ / 2 h / 20 °C

4.1: aq. NaOH / tetrahydrofuran; methanol / 3.5 h / 20 °C

5.1: 94 percent / EDCI / CH₂Cl₂ / 3.5 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo060296c