Technology Process of N-benzyl-7α-vinyl-8α-(formylmethyl)-endo-ethylenetetrahydronorthebaine
There total 11 articles about N-benzyl-7α-vinyl-8α-(formylmethyl)-endo-ethylenetetrahydronorthebaine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
toluene; benzene;
for 20h;
Ambient temperature;
DOI:10.1021/jm00394a016
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 84 percent / Et3N / CH2Cl2 / Ambient temperature
2: 99 percent / benzene / 7 h / Heating
3: 64 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / Heating
4: 1.) KH, 2.) n-BuLi
5: 99 percent / oxalyl chloride, DMSO / CH2Cl2 / 1 h / -78 - -40 °C
6: 99 percent / tetrahydrofuran / 48 h / Ambient temperature
7: potassium hydride / tetrahydrofuran / 22 h / Ambient temperature
8: 85 percent / 6 N aq. HCl / methanol / Ambient temperature
9: Et3N / CH2Cl2 / 0.17 h / 0 °C
10: dimethylsulfoxide / 46 h / 70 °C
11: 88 percent / DIBAL / benzene; toluene / 20 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; potassium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1021/jm00394a016
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 84 percent / Et3N / CH2Cl2 / Ambient temperature
2: 99 percent / benzene / 7 h / Heating
3: 64 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / Heating
4: 1.) KH, 2.) n-BuLi
5: 99 percent / oxalyl chloride, DMSO / CH2Cl2 / 1 h / -78 - -40 °C
6: 99 percent / tetrahydrofuran / 48 h / Ambient temperature
7: potassium hydride / tetrahydrofuran / 22 h / Ambient temperature
8: 85 percent / 6 N aq. HCl / methanol / Ambient temperature
9: Et3N / CH2Cl2 / 0.17 h / 0 °C
10: dimethylsulfoxide / 46 h / 70 °C
11: 88 percent / DIBAL / benzene; toluene / 20 h / Ambient temperature
With
hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; potassium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1021/jm00394a016
