4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium

Base Information

Chemical Name:4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium
CAS No.:1433198-18-5
Molecular Formula:C₂₆H₂₉FN₃O₃
Molecular Weight:450.533
Hs Code.:

Synonyms:4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium

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Chemical Property of 4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium

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Technology Process of 4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium

There total 4 articles about 4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1433198-43-6
2-(4-(4-fluorophenoxy)phenyl)-6-methyl-N-(2-morpholinoethyl)isonicotinamide

: 74-88-4
methyl iodide

: 1433198-18-5
4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Reference yield:

: 3998-90-1
2-chloro-6-methyl-isonicotinic acid methyl ester

: 1433198-18-5
4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane; ethanol / 16 h / 80 °C

1.2: 18 h / 20 °C

2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.33 h / 20 °C

2.2: 20 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1355052-34-4
2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1433198-18-5
4-[2-({2-[4-(4-fluoro-phenoxy)-phenyl]-6-methyl-pyridine-4-carbonyl}-amino)-ethyl]-4-methyl-morpholin-4-ium

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / water; 1,2-dimethoxyethane; ethanol / 16 h / 80 °C

1.2: 18 h / 20 °C

2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 0.33 h / 20 °C

2.2: 20 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;