2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

Base Information

Chemical Name:2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester
CAS No.:182866-64-4
Molecular Formula:C₁₆H₂₀N₂O₆
Molecular Weight:336.345
Hs Code.:

Synonyms:2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

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Chemical Property of 2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

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Technology Process of 2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

There total 5 articles about 2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 24762-04-7
2-Diazo-3-oxo-butyric acid methyl ester

: 13139-27-0
L-α-N-Cbz-alaninamide

: 182866-64-4
2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

Guidance literature:: dirhodium tetraacetate; In chloroform; for 0.5h; Heating;
DOI:10.1039/a704093h

Reference yield: 64.0%

: 2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-hydroxybutyric acid methyl ester

: 182866-64-4
2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 182866-64-4
2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 0.5 h / 0 °C

2: aq. NH₃ / tetrahydrofuran / 0.75 h / 0 °C

3: 71 percent / Rh₂(OAc)4 / CHCl₃ / 0.5 h / Heating

With ammonium hydroxide; triethylamine; dirhodium tetraacetate; In tetrahydrofuran; chloroform;
DOI:10.1039/a704093h