13139-27-0

Basic information

• Product Name: Z-ALA-NH2
• Synonyms: N-CARBOBENZOXY-L-ALANINE AMIDE;N-ALPHA-CARBOBENZOXY-L-ALANINE AMIDE;N-ALPHA-CBZ-L-ALANINE AMIDE;Z-L-ALANINE AMIDE;Z-ALANINE-NH2;Z-ALA-NH2;CBZ-L-ALANINAMIDE;N-(Benzyloxycarbonyl)-L-alaninamide
• CAS NO: 13139-27-0
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24
• EINECS: 1533716-785-6
• Mol File: 13139-27-0.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• Storage Temp.: Store at RT.
• CAS DataBase Reference: Z-ALA-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: Z-ALA-NH2(13139-27-0)
• EPA Substance Registry System: Z-ALA-NH2(13139-27-0)

Safety Data

• Hazardous Substances Data: 13139-27-0(Hazardous Substances Data)

Usage

General Description

Z-ALA-NH2, also known as Z-Alanine amide, is a chemical compound that is derived from the amino acid alanine. It is commonly used in peptide synthesis as a protecting group for the carboxyl group of amino acids. The "Z" in Z-Ala refers to the benzyl group that is attached to the nitrogen atom of the amino acid, providing protection from undesired chemical reactions during peptide synthesis. Z-ALA-NH2 is also used in the pharmaceutical industry for the development of novel drugs and in bioconjugation reactions for the modification of proteins. Overall, Z-ALA-NH2 plays a crucial role in the field of organic chemistry and biochemistry.

Upstream product

• 28819-05-8 (S)-2-benzyloxycarbonylamino-propionic acid methyl ester 
• 62120-85-8 Z-Ala-OBt 
• 25172-67-2 Z-Ala-O-COO-isoBu 
• 1142-20-7 N-benzyloxycarbonyl-L-alanine 
• 3401-36-3 (N-benzyloxycarbonyl)-L-alanine N-hydroxysuccinimide ester 
• 501-53-1 benzyl chloroformate 
• 65638-93-9 N-Carbobenzoxy-L-alanin-kohlensaeureaethylesteranhydrid 
• 1948-31-8 di-L-alanine 
• 2491-20-5 L-alanine methyl ester hydrochloride 
• 1142-20-7 N-Cbz-Ala 

Downstream Products

• 58178-16-8 benzyl (S)-(1-((4-methoxyphenyl)amino)-1-oxopropan-2-yl)carbamate 
• 42166-73-4 (S)-benzyl (1-oxo-1-(phenylamino)propan-2-yl)carbamate 
• 88491-33-2 (S)-N-benzyloxycarbonyl-N'-ethoxycarbonylethane-1,1-diamine 
• 182866-64-4 2'(S)-2-(2-benzyloxycarbonylaminopropionylamino)-3-oxobutyric acid methyl ester 
• 1142-20-7 N-Cbz-Ala 
• 1051922-95-2 C₁₉H₂₄N₂O₅ 
• 400652-46-2 ((S)-2-amino-1-methyl-ethyl)-carbamic acid benzyl ester 
• 89625-83-2 N-carboxybenzoxy-L-alanyl-D,L-2-hydroxyglycine benzyl ester 

Relevant articles and documents

Acyclic chiral amines and amino acids as inexpensive and readily tunable catalysts for the direct asymmetric three-component Mannich reaction

The direct three-component asymmetric Mannich reaction catalyzed by acyclic chiral amines or amino acids is presented. Simple acyclic chiral amines and amino acids - such as alanine-tetrazole (9), alanine, valine, and serine - catalyzed the three-componen

Enzymatic ammoniolysis of amino acid derivatives

The ammoniolysis of amino acid esters and their derivatives was performed with lipases and proteases yielding the corresponding amino acid amides with moderate to high enantioselectivity.Phenylglycine methyl ester racemized slowly under the reaction conditions.

ANTIBACTERIAL COMPOUND AND USES OF SAME

A new compound exhibiting particularly advantageous antibacterial properties, and having the structural formula: L-pyroglutamyl-L-1-aminoethyltetrazole (or N-(1-(1H-tetrazol-5-yl)ethyl)-5-oxopyrrolidine-2-carboxamide). Also, the use of this compound in mi

Selective Removal of Aminoquinoline Auxiliary by IBX Oxidation

8-Aminoquinoline (AQ) is a widely used bidentate auxiliary in metal-catalyzed directed C-H functionalization reactions. Herein, we report an efficient and chemoselective method to convert various N-quinolyl carboxamides to primary amides with the treatment of a stoichiometric amount of 2-iodoxybenzoic acid oxidant or the combination of a catalytic amount of 2-iodobenzoic acid and Oxone co-oxidant in mixed solvents of H2O and HFIP. Its unique compatibility with the Phth-protected α-amino acid (αAA) substrates enhances the overall synthetic utility of the AQ-directed palladium-catalyzed C-H functionalization strategy for synthesis of complex αAAs.