3-phenyl methylglyoxal dimethyl acetal

Base Information

• Chemical Name: 3-phenyl methylglyoxal dimethyl acetal
• CAS No.: 77252-94-9
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol file: 77252-94-9.mol

Synonyms:3-phenyl methylglyoxal dimethyl acetal

Chemical Property of 3-phenyl methylglyoxal dimethyl acetal

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-phenyl methylglyoxal dimethyl acetal

There total 10 articles about 3-phenyl methylglyoxal dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-trimethoxy-N-methyl-acetamide (1401816-27-0) + benzylmagnesium chloride (6921-34-2) → 3-phenyl methylglyoxal dimethyl acetal (77252-94-9)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

DOI:10.3390/molecules171213864

Reference yield: 65.0%

1-phenyl-1,3-dimethoxy-2-propanone (130895-69-1) → 3-phenyl methylglyoxal dimethyl acetal (77252-94-9)

Guidance literature:

With hydrogenchloride; In methanol; at 55 ℃; for 55h;

Reference yield:

(Z)-2-Hydroxy-3-phenyl-propenal (116204-33-2) → 3-phenyl methylglyoxal dimethyl acetal (77252-94-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N / tetrahydrofuran / 1.5 h / Ambient temperature

2: 1.) TsOH*H₂O, 3 Angstroem mol. sieves; 2.) K₂CO₃ / 1.) MeOH, room temp., 1.5 h; 2.) MeOH, room temp., 10 min

With 3 A molecular sieve; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran;

DOI:10.1055/s-1994-25652

upstream raw materials:

methanol

propargyl benzene

diphenyl diselenide

3-ethylsulfanyl-1-phenyl-propenone

Downstream raw materials:

benzylglyoxal