BOC-4-AMINOCINNAMIC ACID

Base Information

• Chemical Name: BOC-4-AMINOCINNAMIC ACID
• CAS No.: 197073-43-1
• Molecular Formula: C₁₄H₁₇NO₄
• Molecular Weight: 263.293
• Mol file: 197073-43-1.mol

Synonyms:4-(tert-butyloxycarbonylamino)cinnamic acid

Chemical Property of BOC-4-AMINOCINNAMIC ACID

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

BOC-4-AMINOCINNAMIC ACID ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BOC-4-AMINOCINNAMIC ACID

There total 4 articles about BOC-4-AMINOCINNAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + trans-p-aminocinnamic acid (17570-30-8) → 4-(tert-butyloxycarbonylamino)cinnamic acid (197073-43-1)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; at 0 ℃; for 6h;

DOI:10.1021/ja046562q DOI:10.1021/ja043289j

Reference yield: 98.0%

trans-p-aminocinnamic acid (17570-30-8) + 2,2-dimethylpropanoic anhydride (1538-75-6) → 4-(tert-butyloxycarbonylamino)cinnamic acid (197073-43-1)

Guidance literature:

trans-p-aminocinnamic acid; With sodium hydroxide; In 1,4-dioxane; water; at 0 ℃; for 0.5h;

2,2-dimethylpropanoic anhydride; In 1,4-dioxane; water; at 0 ℃; for 18h;

DOI:10.3987/COM-08-S(F)109

Reference yield:

acrylic acid (79-10-7) + tris-(o-tolyl)phosphine (6163-58-2) + tert-butyl (4-bromophenyl)carbamate (131818-17-2) → 4-(tert-butyloxycarbonylamino)cinnamic acid (197073-43-1)

Guidance literature:

With triethylamine; palladium(II) chloride; In dichloromethane; water;

upstream raw materials:

di-tert-butyl dicarbonate

trans-p-aminocinnamic acid

acrylic acid

tris-(o-tolyl)phosphine

Downstream raw materials:

tert-butyl N-{4-[(E)-3-(1H-1,2,3-benzotriazole-1-yl)-3-oxo-1-propenyl]phenyl}carbamate

tert-butyl (4-((E)-3-(((R)-1-(((R)-1-((7-chloroquinolin-4-yl)amino)-1-oxo-4-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-3-oxoprop-1-en-1-yl)phenyl)carbamate