(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester
CAS No.:160036-90-8
Molecular Formula:C₂₉H₄₃Cl₃N₂O₇
Molecular Weight:638.029
Hs Code.:

(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

Synonyms:(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

There total 4 articles about (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: (S)-N-methylphenylalanine trichloroethyl ester

: 160036-89-5
N-((1,1-Dimethylethoxy)carbonyl)-L-Leu-O-L-Leu-OH

: 160036-90-8
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -15 - 20 ℃; for 16h;
DOI:10.1039/c39940002381

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 160036-90-8
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / DMAP, DCC / CH₂Cl₂ / 16 h / -20 - 20 °C

2: 95 percent / H₂ / Pd/C / methanol / 4 h / Ambient temperature

3: 77 percent / bis(2-oxooxazolidin-N-yl)phosphonic chloride, iPr₂NEt / CH₂Cl₂ / 16 h / -15 - 20 °C

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/c39940002381

Reference yield:

: 37755-48-9,40298-04-2
benzyl (2S)-2-hydroxy-4-methylpentanoate

: 160036-90-8
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-3-methyl-1-{methyl-[(S)-2-phenyl-1-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-carbamoyl}-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / DMAP, DCC / CH₂Cl₂ / 16 h / -20 - 20 °C

2: 95 percent / H₂ / Pd/C / methanol / 4 h / Ambient temperature

3: 77 percent / bis(2-oxooxazolidin-N-yl)phosphonic chloride, iPr₂NEt / CH₂Cl₂ / 16 h / -15 - 20 °C

With dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1039/c39940002381