(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester
CAS No.:160036-88-4
Molecular Formula:C₂₄H₃₇NO₆
Molecular Weight:435.561
Hs Code.:

Synonyms:(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

There total 1 articles about (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 37755-48-9,40298-04-2
benzyl (2S)-2-hydroxy-4-methylpentanoate

: 160036-88-4
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at -20 - 20 ℃; for 16h;
DOI:10.1039/c39940002381

Reference yield:

: 160036-88-4
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

: 128140-12-5
leualacin

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / H₂ / Pd/C / methanol / 4 h / Ambient temperature

2: 77 percent / bis(2-oxooxazolidin-N-yl)phosphonic chloride, iPr₂NEt / CH₂Cl₂ / 16 h / -15 - 20 °C

3: Zn, 90percent HOAc / 24 h / Ambient temperature

4: 92 percent / O-(1,2-dihydro-2-oxo-1-pyridyl)-1,1,3,3-tetramethyluronium tetrafluoroborate, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / 16 h / 0 °C

5: 95 percent / H₂ / Pd/C / methanol / 4 h / Ambient temperature

6: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / 16 h / -15 - 20 °C

7: 60 percent / pentafluorophenyl diphenylphosphinate / dimethylformamide / 18 h

With pentafluorophenyl diphenyl-phosphinate; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c39940002381

Reference yield:

: 160036-88-4
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

: 160036-93-1
(S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (S)-1-({(S)-1-[2-((R)-1-carboxy-3-methyl-butoxycarbonyl)-ethylcarbamoyl]-2-phenyl-ethyl}-methyl-carbamoyl)-3-methyl-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / H₂ / Pd/C / methanol / 4 h / Ambient temperature

2: 77 percent / bis(2-oxooxazolidin-N-yl)phosphonic chloride, iPr₂NEt / CH₂Cl₂ / 16 h / -15 - 20 °C

3: Zn, 90percent HOAc / 24 h / Ambient temperature

4: 92 percent / O-(1,2-dihydro-2-oxo-1-pyridyl)-1,1,3,3-tetramethyluronium tetrafluoroborate, 1-hydroxybenzotriazole / acetonitrile; dimethylformamide / 16 h / 0 °C

5: 95 percent / H₂ / Pd/C / methanol / 4 h / Ambient temperature

With hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c39940002381