4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

Base Information

Chemical Name:4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide
CAS No.:189268-90-4
Molecular Formula:C₄₀H₄₁Cl₂N₃O₃Si
Molecular Weight:710.775
Hs Code.:

Synonyms:4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

Suppliers and Price of 4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

There total 4 articles about 4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 194928-67-1
(E)-4-(N,N-dimethylcarbamoyl)cinnamic acid

: 189268-27-7
2-aminomethyl-1-[3-(tert-butyldiphenylsilyloxymethyl)-2,4-dichlorophenyl]pyrrole

: 189268-90-4
4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

Guidance literature:: With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm030159x

Reference yield:

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

: 189268-90-4
4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 85.9 percent / acetic acid / 1 h / 90 °C

2.1: CH₂Cl₂ / 1.5 h

2.2: 73.6 percent / DMF / CH₂Cl₂ / 1.5 h / -20 - 20 °C

3.1: 50.2 percent / lithium aluminum hydride / tetrahydrofuran / 1 h

4.1: 100 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

With lithium aluminium tetrahydride; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x

Reference yield:

: 189268-25-5
1-[3-(tert-butyldiphenylsilyloxymethyl)-2,4-dichlorophenyl]pyrrole

: 189268-90-4
4-{(1E)-3-[({1-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichlorophenyl]-1H-pyrrol-2-yl}methyl)amino]-3-oxo-1-propenyl}-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / 1.5 h

1.2: 73.6 percent / DMF / CH₂Cl₂ / 1.5 h / -20 - 20 °C

2.1: 50.2 percent / lithium aluminum hydride / tetrahydrofuran / 1 h

3.1: 100 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

With lithium aluminium tetrahydride; 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x