pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

Base Information

Chemical Name:pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate
CAS No.:1303583-13-2
Molecular Formula:C₂₀H₁₄F₃N₃O₃
Molecular Weight:401.345
Hs Code.:

Synonyms:pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

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Chemical Property of pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

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Technology Process of pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

There total 6 articles about pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 109-00-2
3-HYDROXYPYRIDINE

: 32315-10-9
bis(trichloromethyl) carbonate

: 1303587-79-2
6-(3-(trifluoromethyl)phenyl)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine

: 1303583-13-2
pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 15128-82-2
3-hydroxy-2-nitropyridine

: 1303583-13-2
pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate; bromine / methanol / 0.5 h / 0 °C

1.2: 0.17 h / 0 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

3.1: acetic acid; iron / 5 h / 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 90 °C

5.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 50 °C

6.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; bromine; sodium methylate; iron; potassium carbonate; caesium carbonate; acetic acid; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 443956-08-9
6-bromo-2-nitropyridin-3-ol

: 1303583-13-2
pyridin-3-yl 6-(3-(trifluoromethyl)phenyl)-2H-pyrido[3,2-b][1,4]oxazine-4(3H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C

2: acetic acid; iron / 5 h / 90 °C

3: potassium carbonate / N,N-dimethyl-formamide / 90 °C

4: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 50 °C

5: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With di-isopropyl azodicarboxylate; iron; potassium carbonate; caesium carbonate; acetic acid; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;