2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone

Base Information

Chemical Name:2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone
CAS No.:180211-63-6
Molecular Formula:C₁₆H₂₂O₂
Molecular Weight:246.349
Hs Code.:

Synonyms:2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone

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Chemical Property of 2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone

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Technology Process of 2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone

There total 9 articles about 2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5453-88-3
ethyl 1-methyl-2-oxocyclopentane-1-carboxylate

: 180211-63-6
2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Mg / 1.) THF, reflux, 1 h, 2.) THF, from -40 deg C to RT, 10 h

2: 99 percent / KHSO₄ / 1 h / 140 °C

3: 99 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

4: 48 percent / pyridinium chlorochromate / CH₂Cl₂ / 24 h / 20 °C

5: 50 percent / N₂H₄*H₂O, NaOH / bis-(2-hydroxy-ethyl) ether / 7 h / 195 °C

6: 1.) NaBH₄, BF₃*OEt₂, 2.) 3 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, RT, 20 h, 2.) THF, RT, 2 h

7: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 20 h / Ambient temperature

8: 1.) NaH / 1.) DME, from -50 deg C to 0 deg C, 0.5 h, 2.) DME, a) 0 deg C, 3 h, b) RT, 20 h

With sodium hydroxide; sodium tetrahydroborate; potassium hydrogensulfate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium acetate; sodium hydride; hydrazine hydrate; magnesium; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; diethylene glycol;
DOI:10.1055/s-1996-4309

Reference yield:

: 14804-31-0
2-methyl-4-bromoanisole

: 180211-63-6
2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) Mg / 1.) THF, reflux, 1 h, 2.) THF, from -40 deg C to RT, 10 h

2: 99 percent / KHSO₄ / 1 h / 140 °C

3: 99 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

4: 48 percent / pyridinium chlorochromate / CH₂Cl₂ / 24 h / 20 °C

5: 50 percent / N₂H₄*H₂O, NaOH / bis-(2-hydroxy-ethyl) ether / 7 h / 195 °C

6: 1.) NaBH₄, BF₃*OEt₂, 2.) 3 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, RT, 20 h, 2.) THF, RT, 2 h

7: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 20 h / Ambient temperature

8: 1.) NaH / 1.) DME, from -50 deg C to 0 deg C, 0.5 h, 2.) DME, a) 0 deg C, 3 h, b) RT, 20 h

With sodium hydroxide; sodium tetrahydroborate; potassium hydrogensulfate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium acetate; sodium hydride; hydrazine hydrate; magnesium; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; diethylene glycol;
DOI:10.1055/s-1996-4309

Reference yield:

: 180211-61-4
2-(4-methoxy-3-methylphenyl)-3,3-dimethylcyclopentene

: 180211-63-6
2-(4-methoxy-3-methylphenyl)-2,3,3-trimethylcyclopentanone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaBH₄, BF₃*OEt₂, 2.) 3 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, RT, 20 h, 2.) THF, RT, 2 h

2: pyridinium chlorochromate, NaOAc / CH₂Cl₂ / 20 h / Ambient temperature

3: 1.) NaH / 1.) DME, from -50 deg C to 0 deg C, 0.5 h, 2.) DME, a) 0 deg C, 3 h, b) RT, 20 h

With sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium acetate; sodium hydride; pyridinium chlorochromate; In dichloromethane;
DOI:10.1055/s-1996-4309