5453-88-3

Basic information

• Product Name: ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE
• Synonyms: ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE;ethyl 1-methyl-2-oxocyclopentane-1-carboxylate
• CAS NO: 5453-88-3
• Molecular Formula: C₉H₁₄O₃
• Molecular Weight: 170.20566
• Mol File: 5453-88-3.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 232°Cat760mmHg
• Flash Point: 94.3°C
• Appearance: /
• Density: 1.078g/cm³
• Vapor Pressure: 0.0603mmHg at 25°C
• Refractive Index: 1.462
• CAS DataBase Reference: ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE(5453-88-3)
• EPA Substance Registry System: ETHYL1-METHYL-2-OXOCYCLOPENTANECARBOXYLATE(5453-88-3)

Safety Data

• Hazardous Substances Data: 5453-88-3(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Canadian Journal of Chemistry, 40, p. 353, 1962 DOI: 10.1139/v62-054

InChI:InChI=1/C9H14O3/c1-3-12-8(11)9(2)6-4-5-7(9)10/h3-6H2,1-2H3

Upstream product

• 544-97-8 dimethyl zinc(II) 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 74-83-9 methyl bromide 
• 628-20-6 4-Chlorobutyronitrile 
• 535-11-5 Ethyl 2-bromopropionate 
• 74-88-4 methyl iodide 
• 2900-10-9 ethyl 1-(iodomethyl)-2-oxocyclopentane-1-carboxylate 
• 85725-99-1 methyl-1 oximino-2 cyclopentane carboxylate d'ethyle 
• 98968-97-9 ethyl 2-(1-hexahydroazepinyl) 2-cyclopentenecarboxylate 
• 98968-96-8 ethyl-2-(1-piperidinyl)-1-cyclopentenecarboxylate 
• 40702-70-3 ethyl 2-oxo-cyclopentanecarboxylate potassium salt 
• 112818-11-8 ethyl 2-oxo-1-((phenylseleno)methyl)cyclopentane-1-carboxylate 
• 141-28-6 diethyl adipate 
• 49768-02-7 1-methyl-2-methylen-1-cyclopentancarbonsaeure-aethylester 

Downstream Products

• 91214-21-0 2-methyl-adipic acid diethyl ester 
• 7424-85-3 ethyl 3-methyl-2-oxocyclopentanecarboxylate 
• 37619-50-4 (6-Methyl-1,4-dioxa-spiro[4.4]non-6-yl)-methanol 
• 51965-90-3 ethyl 1-methyl-2-oxocyclopent-3-enecarboxylate 
• 1120-72-5 2-Methylcyclopentanone 
• 1237740-00-9 1-methylcyclopent-2-enecarboxylic acid 
• 16737-07-8 (1,2-dimethylcyclopent-2-en-1-yl)(phenyl)methanone 
• 68752-16-9 1-(1-methyl-2-cyclopenten-1-yl)-ethanone 
• 17197-84-1 5,5-dimethylcyclopent-2-enone 
• 4541-32-6 2,2-dimethylcyclopentanone 
• 51941-55-0 1-Bromo-2-carbethoxy-2-methyl-1-p-tolylcyclopentane 
• 51941-56-1 2-Carbethoxy-1,2-dimethyl-1-p-tolylcyclopentane 
• 51941-58-3 1,2-Dimethyl-2-formyl-1-p-tolylcyclopentane 
• 51941-57-2 1,2-Dimethyl-2-hydroxymethyl-1-p-tolylcyclopentane 

Relevant articles and documents

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Facile synthesis of δ-ketoesters via formal two-carbon insertion into β-ketoesters

A formal two-carbon insertion into β-ketoesters with vinylmetal has been developed for the rapid synthesis of δ-ketoesters. This method features high efficiency, simple operation, and mild conditions without the usage of bases and catalysts. The reaction is postulated to proceed via a tandem process involving nucleophilic addition of vinylmetal to ketone, retro-aldol reaction to give an enolate anion and an enone, and finally Michael addition of these two intermediates.

Oxidative umpolung ?±-alkylation of ketones

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A hydroxyl functional group positioned β to a pinacol boronate can serve to direct palladium-catalyzed cross-coupling reactions. This feature can be used to control the reaction site in multiply borylated substrates and can activate boronates for reaction that would otherwise be unreactive.