(R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide

Base Information

Chemical Name:(R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide
CAS No.:347378-41-0
Molecular Formula:C₃₃H₃₁NO₅
Molecular Weight:521.613
Hs Code.:

Synonyms:(R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide

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Technology Process of (R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide

There total 9 articles about (R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 103-80-0
phenylacetyl chloride

: 347378-40-9
(R)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-1-phenylethanolamine

: 347378-41-0
(R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1021/jm001128u

Reference yield:

: 2861-28-1
1,3-benzodioxole-5-acetic acid

: 347378-41-0
(R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / CH₂Cl₂ / 3 h / Heating

2: 92 percent / 4-DMAP; Et₃N / CH₂Cl₂ / 1 h / 20 °C

3: 90 percent / BF₃*etherate; BH₃*THF / tetrahydrofuran / 2.5 h / Heating

4: 60 percent / 4-DMAP; Et₃N / CH₂Cl₂ / 2.5 h / 20 °C

With dmap; thionyl chloride; borane-THF; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm001128u

Reference yield:

: 6845-81-4
3,4-methylenedioxyphenylacetyl chloride

: 347378-41-0
(R)-N-(1-phenyl-2-phenylacetylethoxy)-N-[2-(3,4-methylenedioxyphenyl)ethyl]-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / 4-DMAP; Et₃N / CH₂Cl₂ / 1 h / 20 °C

2: 90 percent / BF₃*etherate; BH₃*THF / tetrahydrofuran / 2.5 h / Heating

3: 60 percent / 4-DMAP; Et₃N / CH₂Cl₂ / 2.5 h / 20 °C

With dmap; borane-THF; boron trifluoride diethyl etherate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm001128u