2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Base Information

Chemical Name:2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine
CAS No.:197151-12-5
Molecular Formula:C₃₅H₅₂N₆O₉Si₂
Molecular Weight:757.004
Hs Code.:

Synonyms:2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

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Chemical Property of 2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

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Technology Process of 2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

There total 8 articles about 2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.5%

: 79-30-1
isobutyryl chloride

: 197151-07-8
2'-O-Allyl-6-O-(2-nitrophenyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

: 197151-12-5
2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Guidance literature:: With pyridine; dmap; at 40 ℃; for 8h;

Reference yield:

: 69304-44-5
3',5'-O-1,1,3,3-tetraisopropyldisiloxan-1,3-diyl-guanosine

: 197151-12-5
2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Guidance literature:: Multi-step reaction with 6 steps

1: dimethylformamide / 0.17 h / 40 °C

2: Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

3: DABCO, Et₃N / acetonitrile / 0.5 h / 80 °C

4: PTSA*H₂O / tetrahydrofuran; CH₂Cl₂ / 0.03 h / Ambient temperature

5: 87.8 percent / 1,4-bis(diphenylphosphino)butane / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / Heating

6: 85.5 percent / pyridine, DMAP / 8 h / 40 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; dmap; toluene-4-sulfonic acid; triethylamine; 1,4-di(diphenylphosphino)-butane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 197151-12-5
2-N-Isobutyryl-6-O-(2-nitrophenyl)-2'-O-allyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)guanosine

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / imidazole / dimethylformamide / 2 h / Ambient temperature

2: dimethylformamide / 0.17 h / 40 °C

3: Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

4: DABCO, Et₃N / acetonitrile / 0.5 h / 80 °C

5: PTSA*H₂O / tetrahydrofuran; CH₂Cl₂ / 0.03 h / Ambient temperature

6: 87.8 percent / 1,4-bis(diphenylphosphino)butane / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 0.5 h / Heating

7: 85.5 percent / pyridine, DMAP / 8 h / 40 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; dmap; toluene-4-sulfonic acid; triethylamine; 1,4-di(diphenylphosphino)-butane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;